Tc-99m MIBI liver imaging for hepatocellular carcinoma: Correlation with P-glycoprotein-multidrug-resistance gene expression

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Title:	Tc-99m MIBI liver imaging for hepatocellular carcinoma: Correlation with P-glycoprotein-multidrug-resistance gene expression
Authors:	Chang, CS;Yang, SS;Yeh, HZ;Kao, CH;Chen, GH
Contributors:	附設醫院核子醫學部;Taichung Vet Gen Hosp, Div Gastroenterol, Taichung, Taiwan;Chung Shan Med Univ, Dept Internal Med, Taichung, Taiwan;China Med Coll Hosp, Dept Nucl Med, Taichung, Taiwan;Natl Young Min Med Univ, Dept Internal Med, Taipei, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:41:46 (UTC+8)
Publisher:	H G E UPDATE MEDICAL PUBLISHING S A
Abstract:	Background: Hypofunction of N-methyl-D-aspartate glutamate receptor bad been implicated in the pathophysiology of schizophrenia. Treatment with D-serine or glycine, endogenous full agonists of the glycine site of N-methyl-D-aspartate receptor, or D-cycloserine, a partial agonist, improve the symptoms of schizophrenia. N-methylglycine (sarcosine) is an endogenous antagonist of glycine transporter-1, which potentiates glycine's action on N-methyl-D-aspartate glycine site and can have beneficial effects on schizophrenia. Methods: Thirty-eight schizophrenic patients were enrolled in a 6-week double-blind, placebo-controlled trial of sarcosine (2 g/d), which was added to their stable antipsychotic regimens. Twenty of them received risperidone. Measures of clinical efficacy and side effects were determined every other week. Results: Patient who received sarcosine treatment revealed significant improvements in their positive, negative, cognitive, and general psychiatric symptoms. Similar therapeutic effects were observed when only risperidone-treated patients were analyzed. Sarcosine was well-tolerated, and no significant side effect was noted. Conclusions: Sarcosine treatment can benefit schizophrenic patients treated by antipsychotics including risperidone. The significant improvement with the sarcosine further supports the hypothesis of N-methyl-D-aspartate receptor hypofunction in schizophrenia. Glycine transporter-1 is a novel target for the pharmacotherapy to enhance N-methyl-D-aspartate function.
Relation:	HEPATO-GASTROENTEROLOGY 51(55):211-214
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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