Elevated F-18-FDG uptake in skeletal muscles and thymus: a clue for the diagnosis of Graves' disease

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Title:	Elevated F-18-FDG uptake in skeletal muscles and thymus: a clue for the diagnosis of Graves' disease
Authors:	Chen, YK;Chen, YL;Liao, AC;Shen, YY;Kao, CH
Contributors:	附設醫院核子醫學部;Shin Kong Wu Ho Su Mem Hosp, Dept Endocrinol & Metab, Taipei, Taiwan;Shin Kong Wu Ho Su Mem Hosp, Dept Nucl Med, Taipei, Taiwan;China Med Coll Hosp, Dept Nucl Med, Taichung, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:41:44 (UTC+8)
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Abstract:	The formation of N-(2-hydroxyethyl)valine (HEV) in hemoglobin has been considered as a biomarker to assess exogenous and endogenous exposures to ethylene oxide (EO) and/or ethylene (ET). Factors associated with daily exposures to such compounds might significantly affect the formation of HEV Tobacco smoke containing EO elicited a significant increase in the levels of HEV amongst smokers, although other factors related to lifestyles may warrant further studies. The objective of this study was to specifically analyze HEV using a modified Edman degradation technique in order to study the association between lifestyle related factors (smoking, second-hand smoke exposure, tea and alcohol consumption) and HEV formation in vivo. Total of 148 Taiwanese volunteers with no history of occupational exposure to either EO or ET were recruited in this study. The HEV levels for smokers (204 +/- 151 pmol HEV/g globin, n = 70) were greater than those for non-smokers (57 +/- 46 pmol HEV/g globin, n = 78), HEV level increasing with the number of cigarettes smoked by subjects per day with a rate of 8.8 pmol HEV/g globin per cigarettes per day. Further analysis revealed that the rate of HEV formation in our study subjects was significantly associated with the number of daily cigarettes smoked (P < 0.001), but was not associated with tea or alcohol consumption, second-hand smoke exposure, subject age, or subject gender. These results suggest that the significantly higher levels of HEV for smokers than for non-smokers were mainly due to subject exposure to EO contained in cigarette smoke. (C) 2004 Elsevier B.V. All rights reserved.
Relation:	NUCLEAR MEDICINE COMMUNICATIONS 25(2):115-121
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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