Predicting chemotherapy response to paclitaxel-based therapy in advanced non-small-cell lung cancer with P-glycoprotein expression

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Title:	Predicting chemotherapy response to paclitaxel-based therapy in advanced non-small-cell lung cancer with P-glycoprotein expression
Authors:	Yeh, JJ;Hsu, WH;Wang, JJ;Ho, ST;Kao, A
Contributors:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;Ping Tung Christian Hosp, Dept Thorac Med, Pingtung, Taiwan;China Med Coll Hosp, Dept Med Res, Taichung 404, Taiwan;China Med Coll Hosp, Dept Internal Med, Div Pulm Crit Care Med, Taichung, Taiwan;Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan;Natl Def Med Ctr, Sch Med, Taipei, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:41:21 (UTC+8)
Publisher:	KARGER
Abstract:	Objective: Osteoporosis is a common disorder with a strong genetic component. Our aim was to investigate the correlations of the interleukin-1beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1Ra) gene polymorphisms with bone mineral density (BMD) and their relationship to osteoporosis. Methods: The IL- 1beta (promoter and exon 5) and IL-1Ra (intron 2) gene polymorphisms were determined using polymerase chain reaction. BMD of the lumbar spine and proximal femur were measured using dual-energy X-ray absorptiometry. Results: The prevalence of each genotype of theinterleukin-1 related genes in the study population was: (1) 14%C/C, 71.5%C/T, and 14.5%T/T in IL-1beta promoter; (2) 95.3% El/El and 4.7% E1/E2 in IL-1beta exon 5; (3) 92.4% I/I, 6.4% I/II, and 1.2% II/II in IL-1Ra intron 2. After adjustment for potential confounding factors such as age, height, weight, years since menopause, and daily calcium intake, subjects with genotype E1/E2(n =8) in IL-1beta exon 5 had lower BMD values and a significantly greater risk for osteoporosis (OR 10.6, 95% Cl 1.3-83.8) at the lumbar spine when compared with subjects with genotype E1/E1 (n = 164) in IL-1beta exon 5. Conchision: The Taq I IL-1beta exon 5 gene polymorphism is associated with reduced BMD and predisposes women to osteoporosis at the lumbar spine, but our results should be interpreted with caution because of the small number of subjects with the unfavorable E1/E2 genotype. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
Relation:	RESPIRATION 70(1):32-35
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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