Technetium-99m tetrofosmin myocardial perfusion single photon emission computed tomography in syndrome X - A preliminary report

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Title:	Technetium-99m tetrofosmin myocardial perfusion single photon emission computed tomography in syndrome X - A preliminary report
Authors:	Hsu, HB;Shiau, YC;Kao, A;Lin, CC;Lee, CC
Contributors:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Med Res, Taichung 404, Taiwan;China Med Coll Hosp, Dept Family Med, Taichung 404, Taiwan;China Med Coll Hosp, Div Cardiol, Taichung 404, Taiwan;Natl Taiwan Univ, Coll Elect Engn, Far Eastern Mem Hosp, Inst Biomed Engn,Dept Nucl Med, Taipei 10764, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:40:50 (UTC+8)
Publisher:	JAPAN HEART JOURNAL, SECOND DEPT OF INTERNAL MED
Abstract:	Although Serratia marcescens is a common cause of nosocomial infection in Taiwan, strains producing extended-spectrum beta-lactamases (ESBLs) are rare. We detected four clinical isolates of S. marcescens from Taiwan that exhibited resistance to cefotaxime (MICs, > 256 mug/ml) and cefepime (MICs, greater than or equal to 32 mug/ml), but were susceptible to imipenem and meropenem. Transconjugants revealed similar MIC profiles when compared to the parental strains. Isoelectric focusing revealed one major transferable beta-lactamase (pI 8.4), which was further identified as CTX-M-3 by polymerase chain reaction and gene sequencing. An AmpC-like enzyme (pI 8.8) was not transferable. All four isolates had significant MIC reductions of greater than or equal to3 log(2) dilutions for cefepime in the presence of clavulanic acid, compatible with the presence of an ESBL (CTX-M-3). Clavulanate did not significantly reduce the cefotaxime MIC for one isolate that may co-produce high-level AmpC beta-lactamase (pI 8.8). Since high-level AmpC expression has minimal effect on the activity of cefepime, isolates co-producing AmpC beta-lactamase may be recognized as additional ESBL producers by using cefepime as an ESBL screening agent. (C) 2003 Elsevier Science Inc. All rights reserved.
Relation:	JAPANESE HEART JOURNAL 44(2):153-162
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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