Detection of bladder cancer using single-photon emission computed tomography of thallium-201: A preliminary report

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Title:	Detection of bladder cancer using single-photon emission computed tomography of thallium-201: A preliminary report
Authors:	Yang, CC;Shiau, YC;Sun, SS;Kao, CH
Contributors:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Urol, Taichung 404, Taiwan;Far Eastern Mem Hosp, Dept Nucl Med, Taipei, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:40:20 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	We investigated the sub-clinical lung injury in patients with breast cancer after chemotherapy by technetium-99m hexamethylpropylene amine oxime (Tc-99m HMPAO) lung scan. Fifty patients who underivent surgical resection for breast cancers were divided into two groups, those who received a combination of adjuvant chemotherapy and those who did not. Group 1 consisted of 25 patients who received adjuvant chemotherapy and group 2 consisted of 25 patients who did not receive adjuvant chemotherapy. Tc-99m HMPAO lung scan was performed in each patient and the degree of pulmonary vascular endothelium damage was represented as lung/liver uptake ratios (L/L ratio). None of the 50 patients had positive plain chest radiograph (CXR) and pulmonary function test (PFT) findings. The results showed a significantly higher L/L ratio in the group 1 patients (0.57 +/- 0.13) than in the group 2 patients (0.32 +/- 0.05). We conclude that chemotherapeutic drugs may result in pulmonary vascular endothelium damage and that Tc-99m HMPAO lung scan has the potential to be a sensitive, objective and non-invasive method to detect sub-clinical lung injury of patients with breast cancers after chemotherapy.
Relation:	ANTICANCER RESEARCH 23(3C):2977-2980
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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