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http://ir.cmu.edu.tw/ir/handle/310903500/29677
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| 題名: | Compare FDG-PET and Tc-99m tetrofosmin SPECT to detect metastatic thyroid carcinoma |
| 作者: | Chen, YK;Liu, FY;Yen, RF;Kao, CH |
| 貢獻者: | 附設醫院核子醫學部;China Med Univ Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Univ Hosp, PET Ctr, Taichung 404, Taiwan;Shin Kong Wu Ho Su Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Shin Kong Wu Ho Su Mem Hosp, PET Ctr, Taipei, Taiwan;Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei, Taiwan;Natl Taiwan Univ Hosp, PET Ctr, Taipei, Taiwan;Taichung Healthcare & Management Univ, Grad Inst Bioinformat, Taichung, Taiwan |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 14:40:15 (UTC+8) |
| 出版者: | ASSOC UNIV RADIOLOGISTS |
| 摘要: | There are two protease-activated receptors (PARS), PAR I and PAR4, in human platelets. It has been suggested that PAR I mediates platelet responses to low concentrations of thrombin, whereas PAR4 mediates signaling only at high concentrations. In the present study, we used a selective PAR4 blocker, YD-3, to investigate the role of PAR4 in thrombin-induced thromboxane formation in human platelets. YD-3 completely prevented thromboxane production by either a low concentration of thrombin (0.1 U/ml) or the PAR4 agonist peptide GYPGKF In contrast,YD-3 did not affect thromboxane production caused by the PAR I agonist peptide SFLLRN, collagen or arachidonic acid. YD-3 also decreased [H-3]arachidonic acid release from thrombin-stimulated platelets. Moreover, desensitization' of platelets with GYPGKF prevented low thrombin-induced thromboxane formation. The decreased thromboxane production by YD-3 is linked to inhibition of calcium influx in thrombin-stimulated platelets. These results suggest that PAR4 plays an important role in the regulation of thromboxane formation in platelets responding to thrombin through prolonged elevation of [Ca2+](i) and activation of phospholipase A(2). These data also indicate that PAR4 can be activated by relatively low concentrations of thrombin in human platelets. The selective inhibition of thrombin-induced thromboxane production by YD-3 may be of therapeutic benefit for thrombotic diseases. |
| 關聯: | ACADEMIC RADIOLOGY 10(8):835-839 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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