Compare FDG-PET and Tc-99m tetrofosmin SPECT to detect metastatic thyroid carcinoma

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Title:	Compare FDG-PET and Tc-99m tetrofosmin SPECT to detect metastatic thyroid carcinoma
Authors:	Chen, YK;Liu, FY;Yen, RF;Kao, CH
Contributors:	附設醫院核子醫學部;China Med Univ Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Univ Hosp, PET Ctr, Taichung 404, Taiwan;Shin Kong Wu Ho Su Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Shin Kong Wu Ho Su Mem Hosp, PET Ctr, Taipei, Taiwan;Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei, Taiwan;Natl Taiwan Univ Hosp, PET Ctr, Taipei, Taiwan;Taichung Healthcare & Management Univ, Grad Inst Bioinformat, Taichung, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:40:14 (UTC+8)
Publisher:	ASSOC UNIV RADIOLOGISTS
Abstract:	There are two protease-activated receptors (PARS), PAR I and PAR4, in human platelets. It has been suggested that PAR I mediates platelet responses to low concentrations of thrombin, whereas PAR4 mediates signaling only at high concentrations. In the present study, we used a selective PAR4 blocker, YD-3, to investigate the role of PAR4 in thrombin-induced thromboxane formation in human platelets. YD-3 completely prevented thromboxane production by either a low concentration of thrombin (0.1 U/ml) or the PAR4 agonist peptide GYPGKF In contrast,YD-3 did not affect thromboxane production caused by the PAR I agonist peptide SFLLRN, collagen or arachidonic acid. YD-3 also decreased [H-3]arachidonic acid release from thrombin-stimulated platelets. Moreover, desensitization' of platelets with GYPGKF prevented low thrombin-induced thromboxane formation. The decreased thromboxane production by YD-3 is linked to inhibition of calcium influx in thrombin-stimulated platelets. These results suggest that PAR4 plays an important role in the regulation of thromboxane formation in platelets responding to thrombin through prolonged elevation of [Ca2+](i) and activation of phospholipase A(2). These data also indicate that PAR4 can be activated by relatively low concentrations of thrombin in human platelets. The selective inhibition of thrombin-induced thromboxane production by YD-3 may be of therapeutic benefit for thrombotic diseases.
Relation:	ACADEMIC RADIOLOGY 10(8):835-839
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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