Detection of recurrent or residual nasopharyngeal carcinomas after radiotherapy with technetium-99m tetrofosmin single photon emission computed tomography and comparison with computed tomography - A preliminary study

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Title:	Detection of recurrent or residual nasopharyngeal carcinomas after radiotherapy with technetium-99m tetrofosmin single photon emission computed tomography and comparison with computed tomography - A preliminary study
Authors:	Tai, CJ;Shiau, YC;Wang, JJ;Ho, YJ;Ho, ST;Kao, CH
Contributors:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Otolaryngol, Taichung 404, Taiwan;Far Eastern Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan;Taipei Municipal Jen Ai Hosp, Dept Radiol, Taichung, Taiwan;Natl Def Med Ctr, Sch Med, Taipei, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:40:07 (UTC+8)
Publisher:	MARCEL DEKKER INC
Abstract:	Objective: In this study, we employed technetium-99m hexamethylpropylene amine oxime (Tc-99m HMPAO) lung scan to detect inhalation lung injury of patients after a fire accident. Methods: Ten healthy men for controls and 10 male patients with pulmonary symptoms/signs from a fire accident were enrolled in this study for comparison. Tc-99m HMPAO lung scan was performed in each control and patient, as well as the degree of pulmonary vascular endothelium damage was represented as lung/liver uptake ratios (L/L ratio). All of the controls and patients had no smoking histories. None of the controls and patients had positive findings of plain chest radiograph (CXR) and pulmonary function test (PFT). Results: The results showed that significantly higher L/L ratio in the 10 patients (0.53 +/- 0.07) than in the 10 controls (0.30 +/- 0.07) (the p value < 0.05). Using a cut-off value of 0.40, all of the 10 patients had abnormally increased L/L ratios. Conclusions: We conclude that Tc-99m HMPAO lung scan has the potential to be a sensitive, objective and noninvasive method to detect inhalation lung injury of patients with pulmonary symptoms/signs but negative CXR and PFT findings after a fire accident.
Relation:	CANCER INVESTIGATION 21(4):536-541
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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