Improving diagnosis of acute appendicitis with atypical findings by Tc-99m HMPAO leukocyte scan

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題名:	Improving diagnosis of acute appendicitis with atypical findings by Tc-99m HMPAO leukocyte scan
作者:	Shung-Shung, S;Yu-Chien, S;Mei-Due, Y;Hwei-Chung, W;Kao, A
貢獻者:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Surg, Taichung, Taiwan;Far Eastern Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Natl Taiwan Univ, Coll Elect Engn, Inst Biomed Engn, Taipei 10764, Taiwan
日期:	2002
上傳時間:	2010-09-24 14:39:25 (UTC+8)
出版者:	SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN
摘要:	The purpose of this study was to evaluate whether vitamin D receptor (VDR) genes Bsml polymorphisms were markers for susceptibility to or severity of systemic lupus erythematosus (SLE) in Chinese patients in Taiwan. The study included 47 Chinese patients with SLE. In addition, 90 unrelated, healthy individuals living in central Taiwan served as control subjects. Each polymorphism was detected as a result of polymerase chain reaction (PCR)-based restriction analysis. A PCR product length was determined to be 580 bp (BB) whereas two fragments of 405 and 175 bp were determined to be excisable lengths (bb) by Bsml endonuclease. The relationship between Bsm polymorphisms and clinical manifestations of SLE was evaluated. We found that BB was significantly more common and bb less common in SLE than in control group (chi(2) = 54.2, P < 0.0001). In addition, the frequency of B allele was also significantly more common in patients with SLE than in the healthy control subjects (chi(2) = 38.7, P < 0.0001), giving an odds ratio of 7.14 (95% confidence interval 3.53 - 14.4). In the SLE patients, we did not detect any associations of VDR genotype with the clinical, laboratory profiles, or lupus nephritis (chi(2) = 2.34, P = 0.3). This study indicated an increased distribution of VDR BB genotype and B allelic frequencies in the Chinese SLE patients in Taiwan. However, there were no associations between the frequency of VDR allelic variations and clinical manifestations, laboratory profiles, or lupus nephritis.
關聯:	NUKLEARMEDIZIN-NUCLEAR MEDICINE 41(1):37-41
顯示於類別:	[台中附設醫院] 期刊論文

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