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http://ir.cmu.edu.tw/ir/handle/310903500/29640
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| 題名: | Comparison of the expression of p-glycoprotein, Ki-67, and p-53 to technetium-99m tetrofosmin mammoscintigraphic findings |
| 作者: | Liu, TJ;Tsai, SC;Ho, YJ;Sun, SS;Kao, CH |
| 貢獻者: | 附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;Taichung Vet Gen Hosp, Dept Surg, Taichung, Taiwan;Natl Taiwan Univ, Coll Elect Engn, Inst Biomed Engn, Far Eastern Mem Hosp Dept Nucl Med, Taipei, Taiwan;Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan;Natl Def Med Ctr, Sch Med, Taipei, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 14:39:23 (UTC+8) |
| 出版者: | MARCEL DEKKER INC |
| 摘要: | CCAAT/enhancer-binding proteins (C/EBPs) are critical transcriptional regulators of differentiation of hematopoietic cells. Previous studies have shown that targeted disruption of the C/ebpalpha gene results in a lack of granulocytic differentiation with an arrest at the stage of immature myeloblasts. By using a gene replacement strategy in which C/EBPbeta was expressed from the C/ebpalpha gene locus of C/EBPalpha-null mice, we have evaluated the ability of C/EBPbeta to function for C/EBPalpha in directing differentiation along the granulocytic pathway. We show that the morphology and the differential cell counts of the bone marrow and peripheral blood cells from C/EBPbeta knockin mice are indistinguishable from those of their wild-type littermates, indicating that hematopoiesis occurs normally in these animals. Additionally, we analyzed expression of 21 myeloid-specific genes, including markers for distinct stages of granulocytic differentiation, and found no significant differences in their levels of expression in the bone marrow of C/EBPbeta knockin and wild-type mice. These results Imply that C/EBPbeta can substitute for C/EBPalpha during hematopoiesis when expressed from the C/ebpalpha gene locus. |
| 關聯: | CANCER INVESTIGATION 20(2):199-205 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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