Comparison of the expression of p-glycoprotein, Ki-67, and p-53 to technetium-99m tetrofosmin mammoscintigraphic findings

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Title:	Comparison of the expression of p-glycoprotein, Ki-67, and p-53 to technetium-99m tetrofosmin mammoscintigraphic findings
Authors:	Liu, TJ;Tsai, SC;Ho, YJ;Sun, SS;Kao, CH
Contributors:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;Taichung Vet Gen Hosp, Dept Surg, Taichung, Taiwan;Natl Taiwan Univ, Coll Elect Engn, Inst Biomed Engn, Far Eastern Mem Hosp Dept Nucl Med, Taipei, Taiwan;Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan;Natl Def Med Ctr, Sch Med, Taipei, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:39:23 (UTC+8)
Publisher:	MARCEL DEKKER INC
Abstract:	CCAAT/enhancer-binding proteins (C/EBPs) are critical transcriptional regulators of differentiation of hematopoietic cells. Previous studies have shown that targeted disruption of the C/ebpalpha gene results in a lack of granulocytic differentiation with an arrest at the stage of immature myeloblasts. By using a gene replacement strategy in which C/EBPbeta was expressed from the C/ebpalpha gene locus of C/EBPalpha-null mice, we have evaluated the ability of C/EBPbeta to function for C/EBPalpha in directing differentiation along the granulocytic pathway. We show that the morphology and the differential cell counts of the bone marrow and peripheral blood cells from C/EBPbeta knockin mice are indistinguishable from those of their wild-type littermates, indicating that hematopoiesis occurs normally in these animals. Additionally, we analyzed expression of 21 myeloid-specific genes, including markers for distinct stages of granulocytic differentiation, and found no significant differences in their levels of expression in the bone marrow of C/EBPbeta knockin and wild-type mice. These results Imply that C/EBPbeta can substitute for C/EBPalpha during hematopoiesis when expressed from the C/ebpalpha gene locus.
Relation:	CANCER INVESTIGATION 20(2):199-205
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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