A gene cluster for the fatty acid catabolism from Pseudonocardia autotrophica BCRC12444

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學檢驗生物技術學系暨碩士班 > 期刊論文 > Item 310903500/29629

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题名:	A gene cluster for the fatty acid catabolism from Pseudonocardia autotrophica BCRC12444
作者:	Chen, CH;Cheng, JC;Cho, JC;Hsu, WH
贡献者:	健康照護學院醫技系;Natl Chung Hsing Univ, Inst Mol Biol, Taichung 402, Taiwan;China Med Univ, Dept Med Lab Sci & Biotechnol, Taichung 404, Taiwan
日期:	2005
上传时间:	2010-09-24 14:39:10 (UTC+8)
出版者:	ACADEMIC PRESS INC ELSEVIER SCIENCE
摘要:	We evaluated the efficacy and toxicity of cisplatin, tegafur plus uracil and leucovorin as neoadjuvant chemotherapy for locally advanced squamous cell carcinoma (SCC) of the oropharynx and hypopharynx. Forty-six patients (stage IV, 83%; N2/3, 52%) were treated with PUL (50 mg/m(2) cisplatin on day 1, 300 mg/m(2) tegafur plus uracil orally and 60 mg leucovorin orally on days 1-14) over a 14-day cycle. Evaluation after 3 cycles led to chemotherapy termination if primary tumor responses were less than partial responses. Otherwise, PUL was continued up to 6 cycles before locoregional therapy. Patients achieving at least good partial responses at the primary site after neoadjuvant chemotherapy received radiotherapy for organ preservation. Chemotherapy responses were analyzed by intent-to-treat. Response rates of primary sites were 71.7% (33 of 46) with 34.8% (16 of 46) showing a complete response. Thirty patients (65.2%) achieved good partial responses at the primary site. Overall response and complete response rates of neck lymph nodes were 68.6% (24 of 35) and 25.7% (nine of 35). The combined response rate of primary site and neck lymph nodes was 63% (95% confidence interval 48.5-77.5%) with a complete response rate of 15.2%. Toxicities of WHO grade 3-4 included anemia (19.6%), diarrhea (17.4%) and neutropenia (8.7%). With a median follow-up of 36 months, overall survival and disease-free survival rates were 45.7% (21 of 46) and 41.3% (19 of 46); organ preservation rate was 90% (19 of 21). We concluded that the outpatient PUL regimen was a moderately effective, less-toxic neoadjuvant chemotherapy for SCC of the oropharynx and hypopharynx. PUL should be studied further with other active agents or radiotherapy. (c) 2005 Lippincott Williams W Wilkins.
關聯:	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 329(3):863-868
显示于类别:	[醫學檢驗生物技術學系暨碩士班 ] 期刊論文

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