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| 題名: | Evaluation of gallbladder function in patients with non-diabetic chronic renal failure by quantitative radionuclide cholescintigraphy |
| 作者: | Kao, MT;Chang, HR;Kao, CH;Lin, CC;Lee, CC |
| 貢獻者: | 附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Coll Hosp, Nephrol Sect, Med Dept, Taichung 404, Taiwan;China Med Coll Hosp, Dept Family Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Med Res, Taichung 404, Taiwan;Chung Shan Med Univ Hosp, Div Nephrol, Taichung, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 14:38:54 (UTC+8) |
| 出版者: | H G E UPDATE MEDICAL PUBLISHING S A |
| 摘要: | Objective: To investigate whether interleukin 1beta (IL-1beta) exon 5 and IL-1 receptor antagonist (IL-1Ra) gene polymorphisms can be used as markers of susceptibility to febrile convulsions in children. Methods: Children were divided into 2 groups: those with febrile convulsions (group 1; n = 51) and normal control subjects (group 2; n = 83). Polymorphisms for IL-1beta exon 5 and IL-1Ra gene polymorphisms were detected by polymerase chain reaction. Genotypes and allelic frequencies for IL-1beta exon 5 and IL-1Ra gene polymorphisms in both groups were compared. Results: Genotype and allele frequencies for IL-1beta exon 5 in both groups were not significantly different. Proportions of E1 homozygotes and E1/E2 heterozygotes for IL-1beta exon 5 were 50 (98.1%) and 1 (1.9%), respectively, in group I and 82 (98.8%) and 1 (1.2%), respectively, in group 2. Frequencies of alleles E1 and E2 for IL-1beta exon 5 were 101 (99.0%) and 1 (1.0%), respectively, in group 1 and 165 (99.4%) and 1 (0.6%), respectively, in group 2. Genotype proportions and allele frequencies for IL-1Ra between groups were significantly different. Proportions of genotypes I/I and I/II for IL-1Ra were 49 (96.1%) and 2 (3.9%) in group 1 and 69 (83.1%) and 14 (16.9%) in group 2. Frequencies of alleles I and 11 for IL-1Ra were 100 (98.0%) and 2 (2.0%) in group I and 152 (91.6%) and 14 (8.4%) in group 2. Conclusions: The IL-1Ra allele I is associated with a higher susceptibility to febrile convulsion, which may become a useful marker for predicting the development of febrile convulsions. The IL-1beta exon 5 gene polymorphisms are not a useful marker for predicting the susceptibility to febrile convulsions. |
| 關聯: | HEPATO-GASTROENTEROLOGY 49(45):613-615 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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