Identification of mimotopes of the Japanese encephalitis virus envelope protein using phage-displayed combinatorial peptide library

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學檢驗生物技術學系暨碩士班 > 期刊論文 > Item 310903500/29605

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题名:	Identification of mimotopes of the Japanese encephalitis virus envelope protein using phage-displayed combinatorial peptide library
作者:	Lin, CW;Wu, SC
贡献者:	健康照護學院醫技系;China Med Univ, Dept Med Lab Sci & Biotechnol, Taichung 404, Taiwan;Natl Tsing Hua Univ, Dept Life Sci, Inst Biotechnol, Hsinchu, Taiwan
日期:	2004
上传时间:	2010-09-24 14:38:42 (UTC+8)
出版者:	KARGER
摘要:	We have previously screened lactic acid bacteria strains from porcine intestine and evaluated their functional properties. We found a strain of Lactobacillus acidophilus LAP5 is with potential for use as human and animal probiotics. However, the safety of the strain in consideration must be evaluated. The present study was conducted to evaluate the toxicity of strain L. acidophilus LAP5 in Wistar rats by dietary administration at concentrations of 2.1 X 10(11), 1.05 x 10(11) and 4.2 x 10(9) CFU per kg body weight of rat per day for 28 days. There were no adverse effects on the general condition and behavior, growth, feed and water consumption, hematology, clinical chemistry indexes, organ weights and histopathologic analysis. Results of this study demonstrated that consumption of strain L. acidophilus IAP5 was not associated with any signs of toxicity in Wistar rats even following consumption of large quantities.
關聯:	JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY 8(1):34-42
显示于类别:	[醫學檢驗生物技術學系暨碩士班 ] 期刊論文

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