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| 題名: | Whole-body 18F-2-deoxyglucose positron emission tomography in primary staging small cell lung cancer |
| 作者: | Shen, YY;Shiau, YC;Wang, JJ;Ho, ST;Kao, CH |
| 貢獻者: | 附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;Shin Kong Wu Ho Su Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Shin Kong Wu Ho Su Mem Hosp, PET Ctr, Taipei, Taiwan;Far Eastern Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan;Natl Def Med Ctr, Sch Med, Taipei, Taiwan;China Med Coll Hosp, PET Ctr, Taichung 404, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 14:38:40 (UTC+8) |
| 出版者: | INT INST ANTICANCER RESEARCH |
| 摘要: | The effects of hydrocortisone on the in vivo acetylation of 2-aminofluorene (AF) and AF-DNA adducts in Sprague-Dawley rats were investigated. Pretreatment with hydrocortisone (50 mg/kg) 48 hours prior to the administration of AF (50 mg/kg) resulted in a 61% and 30% increase, respectively, in the urinary and fecal recovery of N-acetyl- 2-aminofluorene (AAF) and a 36% increase in the metabolic clearance of AF to AAF. Hydrocortisone did not affect Michael's -Menten parameters for N-acetyltransferase (NAT) activity in blood, liver, lung and bladder. Similarly, the apparent value of Km for AF in the examined tissues was not affected by hydrocortisone. However; the apparent value of Vmax for liver NAT activity was significantly increased after hydrocortisone pretreatment. Following exposure of rats to AF with and without pretreatment with hydrocortisone, DNA AF adducts were examined in the target tissue of liver and bladder and also in non-target tissue of lung and circulating leukocytes. The DNA AF adducts in liver, bladder, lung and leukocytes were increased by pretreatment with hydrocortisone. |
| 關聯: | ANTICANCER RESEARCH 22(2B):1257-1264 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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