Gene frequencies of the HPA-1 to HPA-13, Oe and Gov platelet antigen alleles in Taiwanese, Indonesian, Filipino and Thai populations

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Title:	Gene frequencies of the HPA-1 to HPA-13, Oe and Gov platelet antigen alleles in Taiwanese, Indonesian, Filipino and Thai populations
Authors:	Shih, MC;Liu, TC;Lin, IL;Lin, SF;Chen, CM;Chang, JG
Contributors:	健康照護學院醫技系;China Med Univ & Hosp, Dept Med Technol, Taichung, Taiwan;China Med Univ & Hosp, Dept Lab Med, Taichung, Taiwan;Kaohsiung Med Univ Hosp, Div Hemato Oncol, Dept Med, Kaohsiung, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:38:30 (UTC+8)
Publisher:	PROFESSOR D A SPANDIDOS
Abstract:	Two genes, RHD and RHCE, encode the antigens of the RH blood group system. The weak D phenotype is caused by many different RHD alleles encoding aberrant RhD proteins, resulting in distinct serologic phenotypes and anti-D immunization. We analyzed seven weak D phenotypes excluding D-el, using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and direct sequencing methods to detect the changes of all ten RHD exons. The results show that there are four types of weak D in Taiwanese: one case each for CGG to CAG mutation at codon 10, GTG to ATG mutation at codon 174, and GTG to GAG mutation at codon 270, and four cases for GGT to GAT mutation at codon 282. In conclusion, we present the first data of a molecular basis of weak D in Taiwanese, which suggest a clinically relevant potential for anti-D immunization and may improve transfusion strategy in weak D Taiwanese patients.
Relation:	INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 12(4):609-614
Appears in Collections:	[Department of Medical Laboratory Science and Biotechnology ] Journal articles

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