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http://ir.cmu.edu.tw/ir/handle/310903500/29576
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| 題名: | Detection of cervical lymph node metastases in nasopharyngeal carcinomas: comparison between technetium-99m methoxyisobutylisonitrile single photon emission computed tomography and magnetic resonance imaging |
| 作者: | Tai, CJ;Shiau, YC;Tsai, MH;Wang, JJ;Ho, ST;Kao, CH |
| 貢獻者: | 附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Otolaryngol, Taichung 404, Taiwan;Far Eastern Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Coll Elect Engn, Inst Biomed Engn, Taipei, Taiwan;Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan;Natl Def Med Ctr, Sch Med, Taipei, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 14:38:11 (UTC+8) |
| 出版者: | VEDA, SLOVAK ACADEMY SCIENCES |
| 摘要: | Despite advances in morphological imaging, some patients with non-small cell lung cancer (NSCLC) are found to have non-resectable disease at surgery or die of recurrence within a year of surgery. At present, metastatic bone involvement is usually assessed using conventional technetium-99m methylene diophosphate (Tc-99m MDP) whole body bone scan (bone scan), which has a high sensitivity but a poor specificity. We have attempted to evaluate the usefulness of whole body positron emission tomography with 18F-2-deoxyglucose (FDG-PET) for the detection of malignant bone metastases of NSCLC, and to compare FDG-PET results with Bone Scan findings. Forty-eight patients with biopsy-proven NSCLC and suspected to have stage IV disease underwent whole body bone scan and FDG-PET to detect bone metastases. The final diagnoses of bone metastases were established by operative, histopathological findings or clinical follow-up longer than 1 year by additional radiographs or following FDG-PET/Tc-99m MDP bone scan findings showing progressively and extensively widespread bone lesions. A total of 138 bone lesions found on either FDG-PET or Tc-99m MDP bone scan were evaluated. Among the 106 metastatic and 32 benign bone lesions, FDG-PET and Tc-99m MDP bone scan could accurately diagnose 99 and 98, as well as 30 and 2 metastatic and benign bone lesions, respectively. Diagnostic sensitivity and accuracy of FDG-PET and Tc-99m MDP bone scan were 93.4% and 92.5%, as well as 93.5% and 72.5%, respectively. In conclusion, our data suggest that FDG-PET with the same sensitivity and a better accuracy than those of Tc-99m MDP bone scan to detect metastatic bone lesions in patients with biopsy-proven NSCLC and suspected to have stage IV disease. |
| 關聯: | NEOPLASMA 49(4):251-254 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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