Detecting para-aortic lymph nodal metastasis by positron emission tomography of 18F-fluorodeoxyglucose in advanced cervical cancer with negative magnetic resonance imaging findings

CMUR > China Medical University Hospital > Jurnal articles > Item 310903500/29566

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/29566

Title:	Detecting para-aortic lymph nodal metastasis by positron emission tomography of 18F-fluorodeoxyglucose in advanced cervical cancer with negative magnetic resonance imaging findings
Authors:	Yeh, LS;Hung, YC;Shen, YY;Kao, CH;Lin, CC;Lee, CC
Contributors:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung 404, Taiwan;China Med Coll Hosp, PET Ctr, Taichung 404, Taiwan;China Med Coll Hosp, Dept Family Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Med Res, Taichung 404, Taiwan;Shin Kong Wu Ho Su Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Shin Kong Wu Ho Su Mem Hosp, PET Ctr, Taipei, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:37:58 (UTC+8)
Publisher:	PROFESSOR D A SPANDIDOS
Abstract:	We examined the P16 expression by immunohistochemical stain and detected the methylation by methylation specific polymerase chain reaction (MSP) in 48 primary oral squamous cell carcinoma (SCC) tissues. The results showed that 20/48 (41.7%) of cancerous tissues had CpG methylation around the promoter region, but 8/48 (17%) of the nearby non-carcerous tissues also had CpG methylation, around the promoter region. The results from immunohistochemical studies showed that reduced and heterogeneous expression of P16 were found in the tissues, which had CpG methylation around the promoter region. In conclusion, the methylation of P16 in oral SCC occurs in pre-cancerous and cancerous stage, which results in decreasing or abolishing the P16 expression, which is heterogeneous in the cancer cells.
Relation:	ONCOLOGY REPORTS 9(6):1289-1292
Appears in Collections:	[China Medical University Hospital] Jurnal articles

Files in This Item:

There are no files associated with this item.

Loading...