Helicobacter pylori in gastric biopsies of Taiwanese patients with gastroduodenal diseases

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 醫學院 > 醫學檢驗生物技術學系暨碩士班 > 期刊論文 > Item 310903500/29560

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题名:	Helicobacter pylori in gastric biopsies of Taiwanese patients with gastroduodenal diseases
作者:	Lin, CW;Chang, YS;Wu, SC;Cheng, KS
贡献者:	健康照護學院醫技系;China Med Coll, Sch Med Technol, Taichung 404, Taiwan;China Med Coll Hosp, Dept Clin Lab, Taichung, Taiwan;Natl Tsing Hua Univ, Dept Life Sci, Hsinchu, Taiwan
日期:	1998
上传时间:	2010-09-24 14:37:50 (UTC+8)
出版者:	NATL INST INFECTIOUS DISEASES
摘要:	The effect of dopamine hydrochloride on beta(3)-adrenoceptors was studied in isolated adipocytes of Wistar rats using uptake of [C-14]-deoxy-D-glucose (2-DG) as the indicator. Dopamine induced a concentration-dependent decrease of 2-DG uptake into adipocytes in a manner which was not modified by haloperidol at concentrations sufficient to block dopaminergic receptors. Failure of blockade was also observed in samples receiving the pretreatment with a mixture of SCH23390 and domperidone, the dopaminergic antagonists. Absence of dopaminergic receptors in rat white adipocytes was further supported by the findings that dopaminergic agonists did not modify the glucose uptake and the negative response to receptor antibodies in immunoblotting analysis. Pindolol and propranolol reversed this inhibition of dopamine in a concentration-dependent manner. However, this action of dopamine was not affected by prazosin at concentrations sufficient to block alpha-adrenoceptors. Effect of dopamine was reduced in the presence of Rp-cyclic AMPS triethylamine, the membrane-permeable antagonist of cyclic AMP (cAMP), indicating the mediation of cAMP in this inhibition. Direct effect of exogenous dopamine on beta(3)-adrenoceptors was identified using the antibody for beta(3)-adrenoceptors that reversed the inhibition of dopamine. These results suggest that dopamine can activate beta(3)-adrenoceptors to lower glucose uptake into rat white adipocytes which lack dopaminergic receptors. (C) 1998 Elsevier Science B.V. All rights reserved.
關聯:	JAPANESE JOURNAL OF MEDICAL SCIENCE & BIOLOGY 51(1):13-23
显示于类别:	[醫學檢驗生物技術學系暨碩士班 ] 期刊論文

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