中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/29554
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    题名: Exercise and rest technetium-99m-tetrofosmin lung uptake - Correlation with left ventricular ejection fraction in patients with coronary artery disease
    作者: Tsou, SS;Sun, SS;Kao, A;Lin, CC;Lee, CC
    贡献者: 附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Family Med, Taichung 404, Taiwan;China Med Coll Hosp, Div Cardiol, Taichung 404, Taiwan;China Med Coll Hosp, Dept Med Res, Taichung 404, Taiwan
    日期: 2002
    上传时间: 2010-09-24 14:37:39 (UTC+8)
    出版者: JAPAN HEART JOURNAL, SECOND DEPT OF INTERNAL MED
    摘要: This study explored which subtypes of glutamate receptors in the dorsal facial area are involved in the interaction between glutamatergic and serotonergic actions in controlling common carotid arterial blood flow. Microinjection of glutamate (25-100 nmol), N-methyl-D-aspartate (NMDA; 1-4 nmol), or alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA; 0.5-2 nmol) into the dorsal facial area dose-dependently increased common carotid arterial blood flow. The potency order was AMPA>NMDA>glutamate. The glutamate-induced increase in common carotid arterial blood flow was reduced by pretreatment with either D-2-amino-5-phosphonopentanoate (D-AP5; 2.5 - 5.0 nmol), or glutamate diethylester (25-50 nmol). The common carotid arterial blood flow was increased by ketanserin (1.0 nmol) and decreased by (+/-)-1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (1.0 nmol). Both effects were attenuated by pretreatment with either D-AP5 or glutamate diethylester. We conclude that activation of both NMDA and AMPA receptors in dorsal facial area is responsible for the increase in common carotid arterial blood flow, and AMPA receptor may play a greater role. Such response may be suppressed by 5-HT2 action. (C) 2002 Elsevier Science B.V. All rights reserved.
    關聯: JAPANESE HEART JOURNAL 43(5):515-522
    显示于类别:[台中附設醫院] 期刊論文

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