Distributions of p53 codon 72 polymorphism in primary open angle glaucoma

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 中醫學院 > 中醫學系暨碩博班 > 期刊論文 > Item 310903500/2954

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題名:	Distributions of p53 codon 72 polymorphism in primary open angle glaucoma
作者:	林慧茹(Hui-Ju Lin);陳汶吉(Chen Wen-Chi);蔡輔仁(Fuu-Jen Tsai);蔡三章
貢獻者:	中醫學院中醫學系學士班中醫內科學科;中國附醫眼科部
日期:	2002
上傳時間:	2009-08-20 17:57:58 (UTC+8)
摘要:	Background: Glaucomatous neuropathy is a type of cell death by apoptosis. The p53 gene is one of the regulatory genes of apoptosis. Recently, p53 codon 72 polymorphism has been extensively studied to determine the risk factors responsible for many diseases. In the p53 gene, a single base change from G to C causes the alternation of amino acid residue 72 from arginine to proline. In this study the association between p53 codon 72 polymorphism and primary open angle glaucoma (POAG) patients was evaluated. Methods: 58 POAG patients and 59 healthy volunteers were enrolled in this study. Polymerase chain reaction based analysis was used to resolve the p53 codon 72 polymorphism. Results: There were significant differences in the distribution of the polymorphism between the control subjects and the POAG patients (p = 0.00782) The proline form of p53 gene codon 72 appears to be a significant risk factor in the development of POAG (odds ratio 2.389, 95% confidence interval: 1.14 to 5.01). Conclusions: Retinal ganglion cells die during POAG by apoptosis. The tumour suppressor protein, p53, is one of the primary regulators steps of apoptosis, and the results of our study are compatible with this concept.
關聯:	BRITISH JOURNAL OF OPHTHALMOLOGY 86(7):767~770
顯示於類別:	[中醫學系暨碩博班] 期刊論文

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