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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/29543
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| 題名: | Tissue polypeptide specific antigen (TPS) as a tumor marker in renal cell carcinoma |
| 作者: | Chang, CH;Wu, HC;Yen, RF;Kao, A;Lin, CC;Lee, CC |
| 貢獻者: | 附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Med Res, Taichung 404, Taiwan;China Med Coll Hosp, Dept Urol, Taichung 404, Taiwan;China Med Coll Hosp, Dept Family Med, Taichung 404, Taiwan;Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 14:37:24 (UTC+8) |
| 出版者: | INT INST ANTICANCER RESEARCH |
| 摘要: | Our earlier study has demonstrated that following the exposure of rat to the arylamine carcinogen 2-aminofluorene, DNA-2-aminofluorene adducts; were found in the target tissues liver, bladder, colon, lung and also in circulating leukocytes (lymphocytes and monocytes). The result also demonstrated that orally treated antioxidants decreased N-acetylation of 2-aminofluorene in target tissues and leukocytes. Therefore, this study investigated whether quercetin glucuronides could affect N-acetylation of 2-aminofluorene in human acute myeloid leukemia HL-60 cells. Evidence is presented here that human leukemia cells are capable of acetylating 2-aminofluorene. Quercetin glucuronides did inhibit 2-aminofluorene acetylation in intact cells. The results also indicated that quercetin glucuronides induced cytotoxicity in dose-dependent manner in the examined human acute myeloid leukemia HL-60 cells. |
| 關聯: | ANTICANCER RESEARCH 22(5):2949-2950 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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