Tissue polypeptide specific antigen (TPS) and carbohydrate antigen 125 (CA-125) in the early prediction of recurrent ovarian cancer

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Title:	Tissue polypeptide specific antigen (TPS) and carbohydrate antigen 125 (CA-125) in the early prediction of recurrent ovarian cancer
Authors:	Yeh, LS;Hung, YC;Kao, A;Lin, CC;Lee, CC
Contributors:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Med Res, Taichung 404, Taiwan;China Med Coll Hosp, Dept Obstet Gynecol, Taichung 404, Taiwan;China Med Coll Hosp, Dept Family Med, Taichung 404, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:37:19 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	CYFRA 21-1 is a tumor marker that is useful for detecting squamous cell carcinoma (SCC) of the lung. Tissue polypeptide specific antigen (TPS) is a tumor marker that indicates tumor proliferative rate rather than tumor burden. Our aim in this study was to compare the clinical value of CYFRA 21-1 and TPS in the detection of nasopharyngeal carcinoma (NPC). Serum levels of CYTRA 21-1 and TPS were measured in 60 patients with untreated NPC (including 36 differentiated SCC and 24 undifferentiated carcinomas) for comparison with each other. The cut-off values of CYFRA 21-1 and TPS, determined at the 95th percentile of the 43 healthy controls, were 2.50 ng/ml and 115.2 U/l, respectively. The results revealed that the mean serum values of CYTRA 21-1 (620 +/- 5.21 ng/ml) and TPS (153.9 +/- 173 U/l) in all 60 NPC patients were significantly higher than that in the 43 healthy controls (CYTRA 21-1 = 1. 32 - + 0. 50 ng/ml, TPS = 85.0 +/- 16 0 U/l) (p value < 0. 05). In addition, the detecting sensitivities of CYTRA 21-1 (60. 0%) and TPS (58. 3%) for all 60 NPC were not significantly different (p value > 0. 05). In conclusion, our results suggest that both CYFRA 21-1 and TPS are potential tumor markers for the detection of NPC.
Relation:	ANTICANCER RESEARCH 22(6B):3669-3671
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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