Discrepancy between clinical symptoms and Tc-99m MDP bone scan findings before and after strontium-89 therapy for metastatic bone pain of prostate carcinoma

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Title:	Discrepancy between clinical symptoms and Tc-99m MDP bone scan findings before and after strontium-89 therapy for metastatic bone pain of prostate carcinoma
Authors:	Sun, SS;Tsai, SC;Hsieh, JF;Lee, JK;Kao, CH
Contributors:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung, Taiwan;Show Chwan Mem Hosp, Changhua, Taiwan;Chi Mei Fdn Hosp, Tainan, Taiwan;Taichung Vet Gen Hosp, Taichung, Taiwan
Date:	2001
Issue Date:	2010-09-24 14:37:07 (UTC+8)
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Abstract:	Recent studies have suggested that apoptosis is one of the pathogenetic mechanisms in rheumatoid arthritis (RA). In this study, by using single and double immunohistochemical staining assays, Fas, Fas-L, p53, and Bcl-2 were measured simultaneously in RA and osteoarthritic (OA) and post-traumatic (PT) synovial tissues (ST) in order to understand the distribution of these apoptosis-related proteins, The TdT-mediated dUTP-biotin nick end labelling (TUNEL) method was performed to detect apoptotic cells. There was a significant increase of Fas, Fas-L, and p53 in RA ST, compared with OA or PT, but no significant difference of Bcl-2 expression was detected between patient groups. In RA. ST, expression of Fas and p53 was detected in sub-lining layers and the majority of Fas- and p53-expressing cells were fibroblast-like synoviocytes, A positive correlation between Fas and p53 was demonstrated in RA ST. In RA ST, one-third of Fas-positive and 80% of p53-positive cells were also TUNEL-positive, These results indicate that apoptosis in RA is strongly associated with the expression of Fas and p53, but not Bcl-2. Copyright (C) 2000 John Wiley & Sons, Ltd.
Relation:	CLINICAL NUCLEAR MEDICINE 26(2):167-169
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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