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| 題名: | Discrepancy between clinical symptoms and Tc-99m MDP bone scan findings before and after strontium-89 therapy for metastatic bone pain of prostate carcinoma |
| 作者: | Sun, SS;Tsai, SC;Hsieh, JF;Lee, JK;Kao, CH |
| 貢獻者: | 附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung, Taiwan;Show Chwan Mem Hosp, Changhua, Taiwan;Chi Mei Fdn Hosp, Tainan, Taiwan;Taichung Vet Gen Hosp, Taichung, Taiwan |
| 日期: | 2001 |
| 上傳時間: | 2010-09-24 14:37:06 (UTC+8) |
| 出版者: | LIPPINCOTT WILLIAMS & WILKINS |
| 摘要: | Recent studies have suggested that apoptosis is one of the pathogenetic mechanisms in rheumatoid arthritis (RA). In this study, by using single and double immunohistochemical staining assays, Fas, Fas-L, p53, and Bcl-2 were measured simultaneously in RA and osteoarthritic (OA) and post-traumatic (PT) synovial tissues (ST) in order to understand the distribution of these apoptosis-related proteins, The TdT-mediated dUTP-biotin nick end labelling (TUNEL) method was performed to detect apoptotic cells. There was a significant increase of Fas, Fas-L, and p53 in RA ST, compared with OA or PT, but no significant difference of Bcl-2 expression was detected between patient groups. In RA. ST, expression of Fas and p53 was detected in sub-lining layers and the majority of Fas- and p53-expressing cells were fibroblast-like synoviocytes, A positive correlation between Fas and p53 was demonstrated in RA ST. In RA ST, one-third of Fas-positive and 80% of p53-positive cells were also TUNEL-positive, These results indicate that apoptosis in RA is strongly associated with the expression of Fas and p53, but not Bcl-2. Copyright (C) 2000 John Wiley & Sons, Ltd. |
| 關聯: | CLINICAL NUCLEAR MEDICINE 26(2):167-169 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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