Intra-tumoural injection of Y-90 microspheres into an animal model of hepatoma

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Title:	Intra-tumoural injection of Y-90 microspheres into an animal model of hepatoma
Authors:	Chen, SD;Hsieh, JF;Tsai, SC;Lin, WY;Cheng, KY;Wang, SJ
Contributors:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung, Taiwan
Date:	2001
Issue Date:	2010-09-24 14:37:03 (UTC+8)
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Abstract:	Following exposure of rats to the arylamine carcinogen 2-aminofluorene, DNA-carcinogen adducts were found in the liver and bladder target tissues, and also in circulating leucocytes. This work investigated the effect of ellagic acid on arylamine (2-aminofluorene and p-aminobenzoic acid) acetylations in rat leucocytes. Evidence is presented that rat mononuclear leucocytes are capable of acetylating 2-aminofluorene and p-aminobenzoic acid. Both lymphocytes and monocytes were able to acetylate arylamines during 18 h of culture. Cultured lymphocytes produced about twice as much N-acetyl-2-aminofluorene from 2-aminofluorene and 2.2-fold as much N-acetyl-p-aminobenzoic acid from p-aminobenzoic acid as monocytes. After cotreatment with ellagic acid the lymphocyte and monocyte cultures indicated that ellagic acid reduced 2-aminofluorene acetylation.
Relation:	NUCLEAR MEDICINE COMMUNICATIONS 22(2):121-125
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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