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| 題名: | Technetium-99m-tetrofosmin scintigraphy in the prediction of chemotherapy response of untreated malignant lymphomas and comparison with other prognostic factors |
| 作者: | Sun, SS;Tsai, SC;Wang, JJ;Ho, YJ;Ho, ST;Kao, CH |
| 貢獻者: | 附設醫院核子醫學部;Taichung Vet Gen Hosp, Dept Nucl Med, Taichung 407, Taiwan;China Med Coll Hosp, Dept Nucl Med, Taichung, Taiwan;Show Chwan Mem Hosp, Dept Nucl Med, Chunghua, Taiwan;Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan;Jen Ai Hosp, Dept Radiol, Taichung, Taiwan;Natl Def Med Ctr, Tri Serv Gen Hosp, Dept Anesthesiol, Taipei, Taiwan |
| 日期: | 2001 |
| 上傳時間: | 2010-09-24 14:37:00 (UTC+8) |
| 出版者: | INT INST ANTICANCER RESEARCH |
| 摘要: | The CTLA4 (cytotoxic T lymphocyte associated antigen-4) gene encodes the T cell receptor involved in the control of T cell proliferation and mediates T cell apoptosis, C-T polymorphism is present at position -318 from the ATG start codon in the promoter region of the gene. We report a study on the polymorphism in 347 unrelated children with type 1 diabetes mellitus (DM) (age at diagnosis 7.2 +/- 3.8 years) and their 260 healthy siblings as controls. Genotype C/C conferred a risk of type 1 DM (RR = 2.02, 95% CI 1.32-3.10, pc = 0.0033). The gene frequency of the C allele was higher in patients (RR = 1.91, 95% CI 1.28-2.84, pc = 0.0026). The gene frequency and phenotype frequency of the T allele were negatively associated with type 1 DM (RR = 0.52, 95% CI 0.35-0.78, pc = 0.0026 and RR = 0.49, 95% CI 0.32-0.76, pc = 0.0022, respectively). The frequency of genotype C/T was lower in patients (RR = 0.50, 95% CI 0.32-0.78, pc = 0.0051), This study demonstrates that nucleotide -318 C-T polymorphism of the CTLA4 gene is associated with type 1 DM. The promoter allele -318 C confers a risk of type 1 DM but allele -318 T confers protection against this disease. |
| 關聯: | ANTICANCER RESEARCH 21(1B):685-688 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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