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http://ir.cmu.edu.tw/ir/handle/310903500/29521
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| 題名: | Technetium-99m tetrofosmin scintigraphy for detecting malignant lymphoma |
| 作者: | Lee, JK;Tsai, SC;Ho, YJ;Changlai, SP;Kao, CH |
| 貢獻者: | 附設醫院核子醫學部;Taichung Vet Gen Hosp, Dept Nucl Med, Taichung 40705, Taiwan;China Med Coll Hosp, Dept Nucl Med, Taichung, Taiwan;Show Chwan mem Hosp, Dept Nucl Med, Chunghua, Taiwan;JenAi Hosp, Dept Radiol, Taichung, Taiwan;Chung Shan Med & Dent Coll Hosp, Dept Nucl Med, Taichung, Taiwan |
| 日期: | 2001 |
| 上傳時間: | 2010-09-24 14:36:50 (UTC+8) |
| 出版者: | INT INST ANTICANCER RESEARCH |
| 摘要: | The modulation of garlic oil (GO) and three allyl compounds, diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS), on the antioxidation system in rat livers and red blood cells was examined. Rats were orally administered GO (200 mg/kg body weight), DAS (20, 80 mg/kg body weight), DADS (80 mg/kg body weight) or DATS (70 mg/kg body weight) three times a week for 6 weeks. Control rats received corn oil (2 ml/kg body weight) alone. GO, DADS and DATS treatment significantly increased the glutathione (GSH) content (48-84%) in red blood cells (P < 0.05). DATS displayed a greater enhancement than GO and DADS (P < 0.05). Hemolysis induced by tert-butyl hydroperoxide was not suppressed by GO or allyl compound treatment although higher GSH content was evident. Hepatic GSH was not influenced by garlic components. In rat livers, DADS and DATS significantly increased the activity of GSH reductase (46 and 54%, respectively) and of GSH S-transferase (GST) (63 and 103%, respectively), but decreased the GSH peroxidase activity (27 and 28%, respectively). In contrast, GSH reductase and GST activities in the DAS group, either 20 or 80 mg/kg body weight, were similar to the control group. A decrease of GSH peroxidase activity was observed in rats dosed with 80 mg/kg body weight (P < 0.05). An increase in GST activity and a decrease in GSH peroxidase activities were also noted in GO-treated rats (P < 0.05). In red blood cells, three GSH-related antioxidant enzyme activities were not affected by garlic oil and its organosulfur components. Immunoblot assay showed that, accompanying the increase in hepatic GST activity, GO, DADS, DAS (80 mg/kg body weight) and DATS increased the expression of GST Ya, Yb1 and Yc proteins. Results indicate that GO and three allyl compounds play a differential role in modulation of the GSH-related antioxidant system in rat livers and red blood cells. (C) 2001 Elsevier Science Ltd. All rights reserved. |
| 關聯: | ANTICANCER RESEARCH 21(2B):1509-1513 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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