Using radionuclide esophageal emptying test to evaluate pneumatic dilatation effects for achalasia

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Title:	Using radionuclide esophageal emptying test to evaluate pneumatic dilatation effects for achalasia
Authors:	Shen, YY;Shiau, YC;Sun, SS;Kao, CH
Contributors:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;Shin Kong Wu Ho Su Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Natl Taiwan Univ, Coll Elect Engn, Dept Nucl Med, Far Eastren Mem & Inst Biomed Engn, Taipei, Taiwan
Date:	2001
Issue Date:	2010-09-24 14:36:42 (UTC+8)
Publisher:	H G E UPDATE MEDICAL PUBL LTD.
Abstract:	Objectives: The formation of urinary stones is hypothesized to be associated with calcitonin receptors. The most commonly seen polymorphism is C/T at the 1377th nucleotide. Hence, these polymorphisms are being used as a genetic marker in the search for the cause of urolithiasis. Methods: A normal control group of 105 healthy people and 102 patients with recurrent calcium oxalate stones were examined. The polymorphism was detected following a polymerase chain reaction-based and restriction analysis by AluI. An uncuttable length is 228 bp (CC) whereas two fragments of 120 and 108 bp are shown as cuttable lengths (TT). Results: The results revealed significant differences between the normal individuals and the stone patients (p<0.01). The distribution of leucine (cuttable) homozygote in the stone group (2.0%) was higher than in the control group (0.0%). The odds ratio for the leucine allele of the calcitonin receptor gene in calcium oxalate stone disease is 5.634 (95% Cl: 2.286-13.885). Conclusions: Results show that the polymorphism in the calcitonin receptor gene could be a genetic marker for urinary stone disease and therefore it is whorthwhile pursuing further studies of the leucine allele of calcitonin receptor gene due to it is strongly correlated with stone disease. Copyright (C) 2001 S. Karger AG, Basel.
Relation:	HEPATO-GASTROENTEROLOGY 48(40):1061-1063
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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