Scintigraphic evaluation of local recurrence of a primitive neuroectodermal tumor

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Title:	Scintigraphic evaluation of local recurrence of a primitive neuroectodermal tumor
Authors:	Sun, SS;Tsai, SC;Hsu, NY;Kao, CH
Contributors:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 104, Taiwan;China Med Coll Hosp, Div Chest Surg, Taichung 104, Taiwan;Show Chwan Mem Hosp, Dept Nucl Med, Changhua, Taiwan
Date:	2001
Issue Date:	2010-09-24 14:36:22 (UTC+8)
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Abstract:	Purpose: We aimed to investigate if interleukin-1 beta (IL-1 beta) and IL-1 receptor antagonist (IL-IRa) gene polymorphism could be used as markers of susceptibility in endometriosis. Materials and Methods: Women were divided into two groups: 1) endometriosis (n = 120); 2) nonendometriosis groups (n = 103). Polymorphisms for IL-1 beta -511 promoter, IL-1 beta exon 5, and IL-1Ra were detected by polymerase chain reaction. Genotypes and allelic frequencies for these polymorphisms in both groups were compared. Results: Proportions of different IL-1 and IL-1Ra polymorphisms in both groups were nonsignificantly different. Proportions of C homozygote/heterozygote/T homozygote for IL-1 beta -511 promoter in both groups were 1) 21.6/59.1/19.1% and 2) 26.2/50.5/23.3%. Proportions of El homozygote/heterozygote/E2 homozygote for IL-1 beta exon 5 in both groups were 1) 91.6/5/3.3% and 2) 95.15/4.85/0%. Allele I/II/IV/V for IL-1Ra in both groups were 1) 92.5/5.4/1.6/0.4% and 2) 95.1/3.9/1/0%. Conclusions. Association of endometriosis with IL-1 beta -511 promoter, IL-1 beta exon 5, and IL-1 receptor antagonist gene polymorphisms doesn't exist. These polymorphisms are not useful markers for prediction of endometriosis susceptibility.
Relation:	CLINICAL NUCLEAR MEDICINE 26(9):799-800
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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