Incidental visualization of pancreatic cancer on Tc-99m MDP bone scan

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Title:	Incidental visualization of pancreatic cancer on Tc-99m MDP bone scan
Authors:	Sun, SS;Tsai, MK;Chen, CA;Kao, CH
Contributors:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;Kuang Tien Gen Hosp, Dept Nucl Med, Taichung, Taiwan;Kuang Tien Gen Hosp, Dept Radiol, Taichung, Taiwan
Date:	2001
Issue Date:	2010-09-24 14:36:11 (UTC+8)
Publisher:	LIPPINCOTT WILLIAMS & WILKINS
Abstract:	1 This study demonstrated aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell lines CH27 (human lung squamous carcinoma cell) and H460 (human lung non-small cell carcinoma cell). Aloe-emodin- and emodin-induced apoptosis was characterized by nuclear morphological changes and DNA fragmentation. 2 During apoptosis, an increase in cytochrome c of cytosolic fraction and activation of caspase-3, identified by the cleavage of its proform, were observed. 3 To elucidate whether the expression of protein kinase C (PKC) isozymes are involved in aloe-emodin- and emodin-induced apoptosis, this study examined the changes of PKC isozymes by Western blotting techniques during aloe-emodin- and emodin-induced apoptosis. 4 The expression of PKC isozymes involved in aloe-emodin- and emodin-induced apoptosis of CH27 and H460 cells. In this study, aloe-emodin and emodin induced the changes of each of PKC isozymes in C1127 and H460 cells. 5 The decrease in the expression of PKC delta and epsilon may play a critical role in aloe-emodin- and emodin-induced apoptosis in CH27 and H460 cells. 6 The present study also demonstrated that PKC stimulation occurs at a site downstream of caspase-3 in the emodin-mediated apoptotic pathway.
Relation:	CLINICAL NUCLEAR MEDICINE 26(11):971-971
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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