Two incorrect FDG positron emission tomographic interpretations of a pulmonary mass and mediastinal lymphadenopathy

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29492

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题名:	Two incorrect FDG positron emission tomographic interpretations of a pulmonary mass and mediastinal lymphadenopathy
作者:	Kao, CH;Tsai, SC;Hung, GU
贡献者:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;Show Chwan Mem Hosp, Dept Nucl Med, Chunghua, Taiwan;Taichung Vet Gen Hosp, Dept Nucl Med, Taichung, Taiwan
日期:	2001
上传时间:	2010-09-24 14:35:57 (UTC+8)
出版者:	LIPPINCOTT WILLIAMS & WILKINS
摘要:	Aims: This is a retrospective and adaptive randomization study. The purpose of this study was to evaluate the relationship between technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI) chest-imaging results, chemotherapy response and P-glycoprotein (Pgp) or multidrug resistance related protein (MRP) expression in small-cell lung cancer (SCLC). Patients and methods: Before chemotherapy, 30 patients (11 females, 19 males, ages: 52-69 years) with SCLC, including 14 extensive diseases without localized problems and 16 limited diseases in excess of solitary pulmonary nodule, underwent early chest imaging, including visual interpretation and quantitative analyses of tumor uptake ratio (TUR), 10 minutes after intravenous injection of Tc-99m MIBI. Immunohistochemical analyses were performed, using multiple nonconsecutive sections of the biopsy specimens, to detect Pgp and MRP expressions. Chemotherapy response was evaluated in the third month after completion of treatment by clinical and radiological methods. Results: All 15 (100%) of the SCLC patients with complete or partial response had positive Tc-99m MIBI chest SPECT results, but negative ones for both Pgp and MRP expression. Twelve of the 15 (80%) SCLC patients with no response or progressive disease had negative Tc-99m MIBI chest SPECT results and were positive for either Pgp or MRP expression (P < 0.05). Negative Tc-99m MIBI chest SPECT results predicted complete or partial response. The TUR of patients with complete or partial response (1.91 +/- 0.29 with a 95% confidence interval (95% CI): 1.75-2.07) was significantly higher than that of patients with no response or progressive disease (1.19 +/- 0.28 with a 95% CI: 1.04-1.35). Conclusion: Tc-99m MIBI chest images are a potential tool for understanding Pgp and MRP expressions in SCLC and for predicting patient chemotherapy response.
關聯:	CLINICAL NUCLEAR MEDICINE 26(12):1049-1050
显示于类别:	[台中附設醫院] 期刊論文

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