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| 題名: | Technetium-99m tetrofosmin chest imaging related to P-glycoprotein expression for predicting the response with paclitaxel-based chemotherapy for non-small cell lung cancer |
| 作者: | Shiau, YC;Tsai, SC;Wang, JJ;Ho, YJ;Ho, ST;Kao, CH |
| 貢獻者: | 附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;Natl Taiwan Univ, Coll Elect Engn, Inst Biomed Engn, Far Eastern Mem Hosp,Dept Nucl Med, Taipei 10764, Taiwan;Show Chwan Mem Hosp, Dept Nucl Med, Changhua, Taiwan;Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan;Jen Ai Hosp, Dept Radiol, Taichung, Taiwan;Natl Def Med Ctr, Sch Med, Taipei, Taiwan |
| 日期: | 2001 |
| 上傳時間: | 2010-09-24 14:35:39 (UTC+8) |
| 出版者: | SPRINGER-VERLAG |
| 摘要: | Osteoporosis is a common disorder with a strong genetic component. Our aim was to evaluate the correlation of the vitamin D receptor gene intron 8 BsmI polymorphism with bone mineral density (BMD) and their relationship to osteoporosis. We determined the vitamin D receptor gene intron 8 BsmI polymorphism using polymerase chain reaction-based restriction analysis in 171 postmenopausal Chinese women in Taiwan. The polymorphism was detected using the restriction enzyme BsmI. where the B allele indicated absence of the cuttable site and the b allele its presence. BMD of the lumbar spine and proximal femur were measured using dual-energy X-ray absorptiometry. The allelic frequencies for postmenopausal Chinese women in Taiwan were 12.3% for B and 87.7% for b in BsmI restriction fragment length polymorphisms. The prevalence of each genotype in the study population was: 6.4% BB, 11.7% Bb and 81.9% bb. The three genotypic groups differed significantly in BMD at the lumbar spine and the femoral neck. These differences corresponded to significant gene-dose effects at the lumbar spine and femoral neck (p<0.001 for both sites). The relative risk for the development of osteoporosis was about 2-3 times as great as that predicted by the differences between genotypes in BMD, and remained significant even after adjustment for age. height and weight. The vitamin D receptor gene intron 8 BsmI polymorphism is associated with reduced BMD and predisposes women to osteoporosis. |
| 關聯: | LUNG 179(4):197-207 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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