Differentiating benign and malignant pulmonary lesions with FDG-PET

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Title:	Differentiating benign and malignant pulmonary lesions with FDG-PET
Authors:	Yang, SN;Liang, JA;Lin, FJ;Kwan, AS;Kao, CH;Shen, YY
Contributors:	附設醫院核子醫學部;China Med Coll Hosp, Dept Nucl Med, Taichung 404, Taiwan;China Med Coll Hosp, PET Ctr, Taichung 404, Taiwan;China Med Coll Hosp, Dept Radiat Therapy & Oncol, Taichung 404, Taiwan;Chung Shan Med & Dent Coll Hosp, PET Ctr, Taichung, Taiwan;Shin Kong Wu Ho Su Mem Hosp, Dept Radiat Therapy & Oncol, Taipei, Taiwan;Shin Kong Wu Ho Su Mem Hosp, Dept Nucl Med, Taipei, Taiwan;Shin Kong Wu Ho Su Mem Hosp, PET Ctr, Taipei, Taiwan
Date:	2001
Issue Date:	2010-09-24 14:35:37 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	Our aim was to use technetium-99m tetrofosmin (Tc-TF) uptake in non-small cell lung cancer (NSCLC) for predicting the chemotherapeutic response of NSCLC to paclitaxel and to compare the results with the expression of multidrug resistance (MDR)-P-glycoprotein (Pgp). Twenty patients with advanced NSCLC were enrolled in this study before chemotherapy with paclitaxel. Tc-TF chest imaging was performed to calculate early and delayed tumor-to-normal lung (T/NL) count-density ratios, as well as washout indexes (WIs). Immunohistochemical analyses were performed on multiple nonconsecutive sections of the biopsy specimens to detect Pgp expression. The response to chemotherapy was evaluated by clinical and radiological methods in the third month after completion of treatment. The early and delayed T/NL count-density ratios of patients with good response were significantly higher than those of patients with poor response (p<0.05). However, no significant difference in WI between the two groups of patients was found (p>0.05). A significantly higher incidence of good response was found in patients with negative Pgp expression (100%) than in patients with positive Pgp expression (40%) (p<0.05). Significantly higher early and delayed T/NL count-density ratios as well as decreased WIs were found in patients with negative Pgp expression than in patients with positive Pgp expression. However, other prognostic factors (age, sex, body weight loss, performance status, tumor stage, and tumor cell type) were not significantly different between the patients with good response and those with poor response. Because Tc-TF chest images can correctly represent the expression of Pgp in NSCLC, it can accurately predict the chemotherapeutic response to paclitaxel.
Relation:	ANTICANCER RESEARCH 21(6A):4153-4157
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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