Inhibition of phospholipase C gamma 1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla

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Title:	Inhibition of phospholipase C gamma 1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla
Authors:	Lee, JS;Kim, J;Kim, BY;Lee, HS;Ahn, JS;Chang, YS
Contributors:	附設醫院核子醫學部;Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea;Korea Res Inst Biosci & Biotechnol, Taejon 305600, South Korea;China Med Coll, Taichung, Taiwan
Date:	2000
Issue Date:	2010-09-24 14:35:23 (UTC+8)
Publisher:	AMER CHEMICAL SOC
Abstract:	Background/Aims: In patients with liver cirrhosis and ascites, the renin angiotensin system is usually activated. Such a correlation supports the hypothesis that activation of the renin-angiotensin system plays an influential role in the pathogenesis of ascites in liver cirrhosis. Methodology: In this study, 25 patients with liver cirrhosis and ascites (10 females, 15 males; age: 45-67 years) were enrolled. We evaluated the acute effects of converting enzyme inhibitor (a single dose of 50mg captopril taken orally) on glomerular filtration rate, effective renal plasma flow, filtration fraction, plasma renin activity, and plasma aldosterone. Results: Oral intake of a single 50mg dose of captopril significantly decreased glomerular filtration rate (65+/-6mL/min/1.73m(2) vs. 53+/-9mL/min/1.73m(2)), filtration fraction (21.2+/-2.7% vs. 15.5+/-4.1%), and plasma aldosterone (340+/-80pg/mL vs. 247+/-42pg/mL), but increased plasma renin activity (2.65+/-2.19ng/mL/hr vs. 11.58+/-2.70ng/mL/hr) and effective renal plasma flow (312+/-41mL/min/1.73 vs. 356+/-60mL/min/1.73m(2)). Conclusions: We suggest that oral intake of a single dose of 50mg captopril can block the renin-angiotension system, and result in changes in renal hemodynamics and function in cirrhotic patients with ascites.
Relation:	JOURNAL OF NATURAL PRODUCTS 63(6):753-756
Appears in Collections:	[台中附設醫院] 期刊論文

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