Induction of superoxide dismutase isozymes by tumor necrosis factor-alpha and lipopolysaccharide in cultured normal and hyperplastic gingival fibroblasts

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Title:	Induction of superoxide dismutase isozymes by tumor necrosis factor-alpha and lipopolysaccharide in cultured normal and hyperplastic gingival fibroblasts
Authors:	Liu, TZ;Yang, HL;Chan, CP;Pan, WL;Wu, SFK
Contributors:	健康照護學院營養所;CHINA MED COLL,DEPT NUTR,TAICHUNG,TAIWAN;CHANG GUNG MEM HOSP,DEPT PERIODONTOL,KWEI SHAN,TAOYUAN,TAIWAN
Date:	1996
Issue Date:	2010-09-24 14:35:05 (UTC+8)
Publisher:	EXCERPTA MEDICA ASIA LTD
Abstract:	Cotransmission of classic transmitters at the synapse has been mentioned for both the CNS and the PNS. Neuropeptide Y (NPY) is a cotransmitter in noradrenergic neurotransmission, In an attempt to understand the heteroregulation of norepinephrine (NE) and NPY biosynthesis, the present study was performed using radioimmunoassay of NPY and northern blotting of cDNA probes for characterization of NPY mRNA, Values of NPY-like immunoreactivity (NPY-ir) were elevated in the cerebrocortex from rats that received treatment with fusaric acid, an inhibitor of dopamine-beta-hydroxylase, with a parallel decrease in NE, Similar results were also observed in rats treated with DSP-4, an alkylator of vesicles in noradrenergic nerve terminals, Moreover, cerebrocortical NPY-ir was reduced in rats receiving treatment with pargyline, an inhibitor of monoamine oxidase, with an elevation of catecholamine in parallel. Activity of NPY mRNA was modified by these drugs in a similar way, However, values of NPY-ir and NE in the cerebrocortex were not influenced by treatment with sodium nitroprusside or guanethidine at a dose producing hypotensive effect. Mediation of hypotensive reflex can thus be ruled out, The data obtained suggest that in vivo decrease of NE by drugs increases biosynthesis of NPY in the cerebrocortex of rats.
Relation:	JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 95(3):236-240
Appears in Collections:	[Graduate Institute of Nutrition ] Journal articles

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