Surface plasmon resonance detection of interactions between peptide fragments of N-telopeptide and its monoclonal antibodies

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Title:	Surface plasmon resonance detection of interactions between peptide fragments of N-telopeptide and its monoclonal antibodies
Authors:	Lung, FDT;Chen, CH;Liou, CC;Chen, HY
Contributors:	健康照護學院營養系;W China Univ Med Sci, Dept Nutr, Taichung 404, Taiwan;Tunghai Univ, Dept Chem, Taichung 40704, Taiwan;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:34:33 (UTC+8)
Publisher:	BLACKWELL MUNKSGAARD
Abstract:	The present study was designed to investigate the ameliorating effects of Cnidiuim monnieri L. Cusson (CM) and osthole, a constituent of CM, on the spatial performance deficit in scopolamine (SCOP)-treated or ovariectomized (OVA) rats. CM improved the deficit of spatial performance, and reversed the lower plasma estradiol levels caused by SCOP in female rats. In addition, osthole (3 and 10 mg/kg, sc) improved the performance deficit in OVA rats. It (10 and 30 mug/brain, icv) also improved the performance deficit caused by SCOP in intact female rats, and at 30 mug/brain improved the deficit in OVA rats. However, osthole did not alter the latency swum to reach the visible target in SCOP-treated and OVA rats. Accordingly, we suggested that osthole is an active constituent of CM, and possesses ameliorating effects on the spatial performance deficits in SCOP-treated female rats or OVA rats. The action mechanism of the effects of osthole on performance deficits was related to the estrogen-like properties and activating the central cholinergic neuronal system.
Relation:	JOURNAL OF PEPTIDE RESEARCH 63(4):365-370
Appears in Collections:	[Graduate Institute of Nutrition ] Journal articles

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