Expression of mediated P-glycoprotein multidrug resistance related to Tc-99m MIBI scintimammography results

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Title:	Expression of mediated P-glycoprotein multidrug resistance related to Tc-99m MIBI scintimammography results
Authors:	Sun, SS;Hsieh, JF;Tsai, SC;Ho, YJ;Lee, JK;Kao, CH
Contributors:	附設醫院核子醫學部;Taichung Vet Gen Hosp, Dept Nucl Med, Taichung 407, Taiwan;China Med Coll Hosp, Dept Nucl Med, Taichung, Taiwan;Chi Mei Fdn Hosp, Dept Nucl Med, Tainan, Taiwan;Show Chwan Mem Hosp, Dept Nucl Med, Chunghua, Taiwan;Jen Ai Hosp, Dept Radiol, Taichung, Taiwan
Date:	2000
Issue Date:	2010-09-24 14:34:22 (UTC+8)
Publisher:	ELSEVIER SCI IRELAND LTD
Abstract:	Tissue polypeptide specific antigen (TPS) is a new tumor marker that indicates tumor proliferative rate rather than tumor burden. The purpose of this study is to assess the clinical value of TPS in patients with nasopharyngeal carcinoma (NPC). Serum levels of TPS were measured in 60 patients with untreated NPC including 36 squamous cell carcinomas (SCC) and 24 undifferentiated carcinomas. NPC patients were separated into different subgroups based on the International Union Against Cancer (UICC) TNM classification system. Forty three healthy subjects without any evidence of malignancy or other systemic diseases were included as controls. The results showed that (1) the mean serum TPS level of the NPC patients was significantly higher than that of the healthy controls, (2) the mean serum TPS level of NPC patients with SCC was significantly higher than patients with undifferentiated carcinomas, (3) the mean serum TPS levels of NPC patients with higher TNM stages were significantly higher than those with lower TNM stages, (4) the overall diagnostic sensitivity of TPS for NPC is 58.3%, and (5) the overall diagnostic sensitivities of TPS in NPC patients with undifferentiated carcinomas and higher TNM stages were significantly higher than those with SCC and lower TNM stages. In conclusion, our results suggest that TPS may have a potential clinical role as a valuable tumor marker for NPC.
Relation:	CANCER LETTERS 153(1月2日):95-100
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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