Technetium-99m methylene diphosphonate scintimammography for evaluation of palpable breast masses

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Title:	Technetium-99m methylene diphosphonate scintimammography for evaluation of palpable breast masses
Authors:	Lee, JK;Kao, CH;Sun, SS
Contributors:	附設醫院核子醫學部;Taichung Vet Gen Hosp, Dept Nucl Med, Taichung 40705, Taiwan;China Med Coll Hosp, Dept Nucl Med, Taichung, Taiwan
Date:	1999
Issue Date:	2010-09-24 14:34:18 (UTC+8)
Publisher:	PROFESSOR D A SPANDIDOS
Abstract:	Tumor suppressor gene mutations in TSG101, FHIT, and PTEN/MMACl were found in many types of cancer and the defects in these genes are responsible for the tumor development. Since aberrant transcripts of these genes were also identified in normal tissues, the significance of these mutations in carcinogenesis has become a controversy. To determine large deletions or other alterations in these genes, we analyzed the integrity of their transcripts in both cancerous tissues and the matched normal tissues. More than 400 transcripts derived from at least eight different types of tissue were analyzed using nested RT-PCR and direct sequencing. High frequency of abnormal transcripts of all three genes occurred in both cancerous and the: normal tissues. We believe that these aberrant transcripts do not relate to cancer development. These aberrant transcripts may be imperfect products of splicesome that occurs rarely but was amplified by nested RT-PCR. They may be also generated from alternative splicing due to the exonic splicing elements of the gene.
Relation:	ONCOLOGY REPORTS 6(3):659-663
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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