Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse.

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Title:	Estrogen receptor beta gene haplotype is associated with pelvic organ prolapse.
Authors:	陳慧毅(Huey-Yi Chen);萬磊(Lei Wan);鍾雅雯(Ya-Wen Chung);陳汶吉(Chen Wen-Chi);蔡輔仁(Fuu-Jen Tsai)*;蔡長海(Chang-Hai Tsai)
Contributors:	中醫學院中醫學系學士班中醫內科學科;中國附醫婦產部
Keywords:	Pelvic organ prolapse;Estrogen receptor β gene polymorphism;Haplotype
Date:	2008-05
Issue Date:	2009-08-20 17:57:50 (UTC+8)
Abstract:	Objective Estrogen and estrogen receptors are known to play important roles in the pathophysiology of pelvic organ prolapse (POP). We investigated whether estrogen receptor β (ERβ) gene polymorphisms were associated with POP by conducting a case-control association study in 69 women with POP and 141 women without POP. Study design Genotypes of the ERβ gene polymorphisms (rs2987983, rs1271572, rs944459, rs1256049, and rs1255998) were determined by polymerase chain reaction, followed by restriction fragment length polymorphism analysis. Haplotyping analysis was used to determine the relationship among five polymorphisms in the ERβ gene and POP. Results There was no significant difference between women with and those without POP in the distribution of any of the genotypes evaluated. In haplotype frequency estimation analysis, haplotype CGCGC was more prevalent in women with POP (16.7%) than in women without POP (8.9%) (p = 0.011). Using multivariable logistic regression, age, parity and haplotype CGCGC were significantly associated with POP. Conclusion Although the sample size of women with POP studied is small, the present study shows that ERβ gene haplotype may be associated with POP.
Relation:	EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY1(138):105~109
Appears in Collections:	[School of Chinese Medicine] Journal articles

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