Stability and peptide binding specificity of Btk SH2 domain: Molecular basis for X-linked agammaglobulinemia

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Title:	Stability and peptide binding specificity of Btk SH2 domain: Molecular basis for X-linked agammaglobulinemia
Authors:	Tzeng, SR;Pai, MT;Lung, FDT;Wu, CW;Roller, PP;Lei, BF;Wei, CJ;Tu, SC;Chen, SH;Soong, WJ;Cheng, JW
Contributors:	健康照護學院營養系;Natl Tsing Hua Univ, Dept Life Sci, Div Struct Biol & Biomed Sci, Hsinchu 300, Taiwan;China Med Coll, Dept Nutr, Taichung 400, Taiwan;NCI, Med Chem Lab, Div Basic Sci, NIH, Bethesda, MD 20892 USA;Univ Houston, Dept Biol & Biochem, Houston, TX 77204 USA;Univ Washington, Dept Pediat, Seattle, WA 98195 USA;Vet Gen Hosp, Childrens Med Ctr, Dept Pediat, Taipei 112, Taiwan
Date:	2000
Issue Date:	2010-09-24 14:33:29 (UTC+8)
Publisher:	CAMBRIDGE UNIV PRESS
Abstract:	We prospectively studied a total of 24 patients with breast cancer to evaluate the relationship between the degree of accumulation of technetium-99m sestamibi (Tc-99m MIBI) and p-glycoprotein (Pgp) expression in tumor tissues. All 24 patients underwent Tc-99m MIBI scintimammography before surgery or biopsy. Immunohistochemical studies were performed on multiple non-consecutive sections of the same tumor using a Pgp specific monoclonal antibody. JSB-1. Planar images were started 10 min after injection of Tc-99m MIBI. Tumor to background (T/B) ratios calculated from the planar images were correlated with Pgp expression as determined by immunohistochemical studies. The TIE ratios were significantly lower for tumors in eight patients with positive Pgp expression (Group 1) than in 16 patients with negative expression (Group 2) (1.40 +/- 0.11 and 2.76 +/- 0.60, P < 0.05). Our data confirmed that Tc-99m MIBI scintimammography is useful for determination of the presence of multidrug resistance due to Pgp expression in patients with breast cancer. (C) 2000 Elsevier Science Ireland Ltd, All rights reserved.
Relation:	PROTEIN SCIENCE 9(12):2377-2385
Appears in Collections:	[Graduate Institute of Nutrition ] Journal articles

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