中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/29373
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    题名: The impact of the SARS outbreak on an urban emergency department in Taiwan
    作者: Chen, WK;Cheng, YC;Chung, YT;Lin, CC
    贡献者: 附設醫院急診部;China Med Univ Hosp, Dept Emergency Med, Taichung 404, Taiwan;China Med Univ Hosp, Dept Family Med, Taichung 404, Taiwan
    日期: 2005
    上传时间: 2010-09-24 14:33:21 (UTC+8)
    出版者: LIPPINCOTT WILLIAMS & WILKINS
    摘要: A biodegradable composite which was composed of genipin cross-linked gelatin mixing with tricalcium phosphate ceramic particles (GGT) was developed as a bone substitute. This study was evaluated by the biological response of rabbit calvarial bone to assess the potential of the GGT composite as a biodegradable and osteoconductive bone substitute. Eighteen New Zealand white rabbits were used for cranial implantation. Bone defects (15 x 15 mm) of nine rabbits were filled with the GGT composites, while the others were filled with the de-proteinized bovine bones as controls. Three rabbits were examined for each group in every time period at 4. 8 and 12 weeks post-surgery. The assessment included serial post-operative gross examinations, radiographic analyses and histological evaluations. This study demonstrated that this composite is: (1) malleable, with easily molded to the calvarial bone defect without fracture; (2) biocompatible, with no evidence of adverse tissue reaction; (3) osteoconductive, with progressive growth of new bone into the calvarial bone defect; (4) biodegradable, with progressive replacement of the composite by new bone. Additionally. results of both radiographic analyses and histological evaluations revealed obviously greater new bone ingrowth in the GGT composite compared with the de-proteinized bovine bone at the same implantation time. Therefore, the GGT composite could serve as a useful bone substitute for repairing bone defects. (C) 2004 Elsevier Ltd. All rights reserved.
    關聯: MEDICAL CARE 43(2):168-172
    显示于类别:[台中附設醫院] 期刊論文

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