Outcomes of emergency treatment in ruptured hepatocellular carcinoma in the ED

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Title:	Outcomes of emergency treatment in ruptured hepatocellular carcinoma in the ED
Authors:	Chen, WK;Chang, YT;Chung, YT;Yang, HR
Contributors:	附設醫院急診部;China Med Univ Hosp, Dept Emergency Med, Taichung 404, Taiwan;China Med Univ Hosp, Trauma & Emergency Ctr, Taichung 404, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:33:15 (UTC+8)
Publisher:	W B SAUNDERS CO
Abstract:	Introduction: Inflammation might be one of the causes of stone disease. The function of the transporter associated with antigen-processing protein (TAP) is related to immune response and inflammation. Our aim was to investigate the relationship between stone disease and 5 polymorphic sites of the TAP gene ( TAP1- 1, 1- 2, 2- 1, 2- 2, 2 - 3). Materials and Methods: We compared the frequencies of 5 polymorphisms in the TAP gene between 208 patients with recurrent calcium oxalate stone and 210 healthy controls. The polymorphism was detected by polymerase chain reaction-based restriction analysis. Results: Significant differences in the frequency of the polymorphism at the TAP2- 2 site were detected between normal individuals and calcium stone disease patients (p < 0.0001). The distribution of the genotype AA homozygote was higher in stone patients ( 33.3%) than in the control group ( 16.3%). The odds ratio for the A allele compared with the G allele was 2.097 ( 95% CI 1.571 - 2.802). Conclusions: We conclude that the TAP2- 2 Mspl polymorphism might be associated with calcium stone disease. Copyright (c) 2005 S. Karger AG, Basel.
Relation:	AMERICAN JOURNAL OF EMERGENCY MEDICINE 23(6):730-736
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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