Retrospective analysis of inflammatory parameters in acute pyelonephritis

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Title:	Retrospective analysis of inflammatory parameters in acute pyelonephritis
Authors:	Lai, SW;Ng, KC
Contributors:	附設醫院急診部;China Med Coll Hosp, Dept Emergency Med, Taichung, Taiwan;China Med Coll Hosp, Dept Community Med, Taichung, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:33:09 (UTC+8)
Publisher:	TAYLOR & FRANCIS AS
Abstract:	Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from the root and rhizome of Rheum palmatum that has been reported to exhibit antitumor effects through an unknown mechanism. Our study investigated the mechanisms of aloe-emodin-induced cell death in the human lung nonsmall cell carcinoma cell line H460. Aloe-emodin (40 muM)-induced apoptosis of H460 cells involves modulation of cAMP-dependent protein kinase, protein kinase C, Bcl-2, caspase-3 and p38 protein expression. The relationship of various signals, involved in cell death, such as cAMP-dependent protein kinase, protein kinase C, Bcl-2, caspase-3 and p38, has been investigated in the regulation of apoptotic cell death of aloe-emodin. We demonstrated that the expression of p38 is an important determinant of apoptotic death induced by aloe-emodin. (C) 2003 Wiley-Liss, Inc.
Relation:	SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY 37(3):250-252
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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