Body mass index and its related factors in the elderly

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29349

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题名:	Body mass index and its related factors in the elderly
作者:	Lai, SW;Li, TC;Ng, KG
贡献者:	附設醫院急診部;China Med Coll Hosp, Dept Emergency, Taichung 404, Taiwan;China Med Coll Hosp, Dept Community Med, Taichung 404, Taiwan;China Med Coll Hosp, Inst Chinese Med, Taichung 404, Taiwan
日期:	2001
上传时间:	2010-09-24 14:32:53 (UTC+8)
出版者:	ACAD MEDICINE SINGAPORE
摘要:	The fact that vitamin C (ascorbic acid) exhibits a protective effect in certain types of cancer is well documented. Our previous studies demonstrated that human bladder tumor cell line (T24) has N-acetyltransferase (NAT) activity in cytosols and intact cells. The present studies examined the inhibition of arylamine NAT activity and carcinogen (2-aminofluorene)-DNA adduct formation by ellagic acid (EA) in human bladder tumor cell lines (T24 and TSGH 8301). Two assay systems were performed, one with cellular cytosols (9,000 g supernatant), the other with intact bladder tumor cell suspensions. NAT activity and 2-aminofluorene-DNA adduct formation in T24 and TSGH 8301 cells was inhibited by EA in a dose-dependent manner in both systems, i.e., the greater the concentration of EA in the reaction the greater the inhibition of NAT activity (dose- and time-course dependent effects). The data also indicated that EA decreased the apparent Km and Vmax of NAT enzymes from T24 and TSGH 8301 cells in cytosols. NAT activity and 2-aminofluorene-DNA adducts in T24 is higher than in TSGH 8301. This report is the first to demonstrate that EA affects human bladder tumor cell NAT activity.
關聯:	ANNALS ACADEMY OF MEDICINE SINGAPORE 30(4):397-400
显示于类别:	[台中附設醫院] 期刊論文

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