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| 題名: | Correlation of osteoporosis screening by quantitative ultrasound of calcaneus and Osteoporosis Self-Assessment Tool for Asians in Taiwanese |
| 作者: | Hang, NP;Lin, T;Wang, CS;Chou, P |
| 貢獻者: | 附設醫院社區醫學部;Natl Yang Ming Univ, Community Med Res Ctr, Taipei 112, Taiwan;Natl Yang Ming Univ, Inst Publ Hlth, Taipei 112, Taiwan;Tao Yuan Gen Hosp, Dept Orthoped Surg, Dept Hlth, Taipei, Taiwan;China Med Univ & Hosp, Dept Community Med, Taichung, Taiwan;A Lien Community Hlth Ctr, Kaohsiung, Taiwan;Natl Cheng Kung Univ, Inst Publ Hlth, Tainan 70101, Taiwan |
| 日期: | 2004 |
| 上傳時間: | 2010-09-24 14:32:39 (UTC+8) |
| 出版者: | EXCERPTA MEDICA ASIA LTD |
| 摘要: | OBJECTIVE: To investigate whether vascular endothelial growth factor (VEGF) gene 5'-UTR-460 polymorphism could be used as a marker of susceptibility to endometriosis. STUDY DESIGN: Women were divided into 2 groups, endometriosis (n = 122) and nonendometriosis (n = 131). Polymorphisms for VEGF were detected by polymerase chain reaction and BstUI (New England Biolabs, Beverly, Massachusetts) restriction enzyme analysis. Genotypes and allelic frequencies between the groups were compared. RESULTS: Proportions of different VEGF polymorphisms in the groups were significantly different. Proportions of cuttable (C) homozygote/heterozygote/uncuttable (T) homozygote for VEGF in the groups were 0144.3155.7% and 0/63.4/36.6%, respectively. A higher percentage of T/T homozygote and T allele was present in the endometriosis population. The proportions of C/T alleles in the groups were 22.1/77.9% and 31.7/68.3%, respectively. CONCLUSION: T/T homozygotes and the T allele of the VEGF-460 gene are associated with a higher risk of endometriosis. Heterozygotes and C allele are related to the lower risk of endometriosis formation. VEGF polymorphism likely contributes to the pathogenesis of endometriosis and may become a useful marker for predicting endometriosis susceptibility. |
| 關聯: | JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 103(2):130-136 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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