Loperamide increases glucose ultilization in streptozotocin-induced diabetic rats

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 健康照護學院 > 運動醫學系 > 期刊論文 > Item 310903500/29339

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题名:	Loperamide increases glucose ultilization in streptozotocin-induced diabetic rats
作者:	Tzeng, TF;Liu, IM;Lai, TY;Tsai, CC;Chang, WC;Cheng, JT
贡献者:	健康照護學院運醫系;Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 70101, Taiwan;Pao Chien Hosp, Dept Internal Med, Ping Ting, Taiwan;Tajen Inst Technol, Dept Pharm, Yen Pou, Ping Tung Shien, Taiwan;China Med Coll, Dept Sports Med, Taichung, Taiwan;China Med Coll, Sch Postbaccalaureate Chinese Med, Dept Tradit Med, Taichung, Taiwan
日期:	2003
上传时间:	2010-09-24 14:32:35 (UTC+8)
出版者:	BLACKWELL PUBLISHING ASIA
摘要:	1. Tetramethylpyrazine (TMP) is one of the active principles contained in Ligusticum chuanxiong Hort. ( Umbelliferae), a herb that has been used widely in China to treat vascular disorders. 2. In an attempt to elucidate the possible mechanisms of action of TMP, the effect of TMP on intracellular calcium concentrations ([Ca2+](i)) was investigated in cultured vascular smooth muscle (A7r5) cells using the Ca2+ -sensitive dye Fura-2 as an indicator. 3. The increase in [Ca2+](i) in A7r5 cells produced by vasopressin (1 mumol/L) or phenylephrine (1 mumol/L) was attenuated by TMP in a concentration-dependent manner. Only inhibitors specific to ATP-sensitive potassium (K-ATP) channels or small conductance calcium-activated potassium (SKCa) channels attenuated the action of TMP (10 mumol/L) on [Ca2+](i). However, blockers of other K+ channels failed to modify the inhibitory action of TMP (10 mumol/L) on [Ca2+](i). 4. The action of TMP on membrane potential in A7r5 cells was monitored by the fluorescence of bisoxonol. Tetramethylpyrazine caused a concentration-dependent inhibition of changes in membrane potential elicited by KCl ( 20 mmol/L) or phenylephrine ( 1 mumol/L), an effect that was totally reversed by glibenclamide ( 100 mumol/L) and apamin ( 100 nmol/L) in combination. 5. The results obtained indicate that the decrease in [Ca2+](i) in A7r5 cells produced by TMP is mediated mainly by opening of K-ATP and/or SKCa channels.
關聯:	CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 30(10):734-738
显示于类别:	[運動醫學系] 期刊論文

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