Regional differences in responses of rabbit detrusor to electrical and adrenergic stimulation: influence of outlet obstruction

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Title:	Regional differences in responses of rabbit detrusor to electrical and adrenergic stimulation: influence of outlet obstruction
Authors:	Capello, SA;Chou, ECL;Longhurst, PA
Contributors:	附設醫院泌尿部;Albany Med Coll, Div Urol, Albany, NY USA;China Med Coll Hosp, Dept Urol, Taichung, Taiwan;Albany Coll Pharm, Dept Basic & Pharmaceut Sci, Albany, NY USA
Date:	2005
Issue Date:	2010-09-24 14:32:29 (UTC+8)
Publisher:	BLACKWELL PUBLISHING LTD
Abstract:	To evaluate whether polymorphism of the interleukin-4 gene exon 3, and of the interleukin-1beta gene exon 5 and promoter region, are associated with transitional cell carcinoma (TCC) of the urinary bladder, as cytokines are hypothesized to be important in cancer formation. The study included 138 patients with TCC of urinary bladder and 105 healthy controls living in the same area. Each genetic polymorphism was typed using polymerase chain reaction-based restriction analysis. Genotype distribution and allelic frequencies between patients and controls were compared. There were significant differences in genotype and allelic distribution of intron 3 RP1/RP2 polymorphism (P < 0.001), but no significant difference in genotype distribution or allelic frequencies of the interleukin-1beta gene polymorphism between patients with bladder cancer and controls. The interleukin-4 gene intron 3 polymorphism is associated with bladder cancer and is a potential genetic marker in screening for the possible causes of bladder cancer.
Relation:	BJU INTERNATIONAL 95(1):157-162
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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