The expression of vascular endothelial growth factor in transitional cell carcinoma of urinary bladder is correlated with cancer progression

CMUR > China Medical University Hospital > Jurnal articles > Item 310903500/29327

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/29327

Title:	The expression of vascular endothelial growth factor in transitional cell carcinoma of urinary bladder is correlated with cancer progression
Authors:	Yang, CC;Chu, KC;Yeh, WM
Contributors:	附設醫院泌尿部;China Med Coll, China Med Coll Hosp, Dept Urol, Taichung, Taiwan;China Med Coll, China Med Coll Hosp, Dept Pathol, Taichung, Taiwan;Peikang Hosp, China Med Coll, Dept Urol, Peikang, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:32:06 (UTC+8)
Publisher:	ELSEVIER SCIENCE INC
Abstract:	Sonographic evidence of tumor removal by Mammotome(R) excision does not confirm histological clearance. The operator finds it hard to determine if a malignant tumor has been fully removed, leaving a safe margin in the direction of each border; that is, the spatial orientation during tumor retrieval is not well-established by naked eye under sonographic guidance. We propose a computational imaging process to extract reasonable tumor contour in pre- and postoperative data sets for sonographic guidance so that Mammotome(R) excision can help the operator to evaluate the surgical outcome. There were five tumors in the study, including three benign and two malignant. The lesion of interest was delineated after 2-D examination was completed, then it was analyzed with 3-D breast ultrasound (US). To give a reference point for correlations between pre- and postoperative images, we used a marker tape pasted on the skin within the transducer scanning area and then the preoperative 3-D US images were obtained. Subsequently, 2-D breast US was applied during Mammotome(R) operation. After the Mammotome(R) procedures were finished, the postoperative 3-D US images were obtained; thus, we gained two different data sets of 3-D US images that were used for later analysis for evaluating the extension of postoperative margin status. From the results, the safe margin was not satisfactory in all directions, because the minimum differences measured by the proposed algorithm were not large enough in all five cases, and this was proved from two malignant mastectomy specimens. The experimental results representing this inadequate Mammotome(R) excision can be visualized through the computer aid. The comparison of tumor contour and excision margin may possibly be used for small malignant tumors in the future to improve the breast-conserving surgery.
Relation:	UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 22(1):1-6
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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