P53 gene codon 72 polymorphism but not tumor necrosis factor-alpha gene is associated with prostate cancer

CMUR > China Medical University Hospital > Jurnal articles > Item 310903500/29322

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/29322

Title:	P53 gene codon 72 polymorphism but not tumor necrosis factor-alpha gene is associated with prostate cancer
Authors:	Wu, HC;Chang, CH;Chen, HY;Tsai, FJ;Tsai, JJP;Chen, WC
Contributors:	附設醫院泌尿部;China Med Coll Hosp, Dept Urol, Taichung, Taiwan;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung, Taiwan;China Med Coll Hosp, Dept Med Genet, Taichung, Taiwan;China Med Coll Hosp, Dept Pediat, Taichung, Taiwan;Taichung Healthcare & Management Univ, Grad Inst Bioinformat, Taichung, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:31:59 (UTC+8)
Publisher:	KARGER
Abstract:	This study combines an ergometric wheelchair, a six-camera video motion capture system and a prototype computer graphics based musculoskeletal model (CGMM) to predict shoulder joint loading, muscle contraction force per muscle and the sequence of muscular actions during wheelchair propulsion, and also to provide an animated computer graphics model of the relative interactions. Five healthy male subjects with no history of upper extremity injury participated. A conventional manual wheelchair was equipped with a six-component load cell to collect three-dimensional forces and moments experienced by the wheel, allowing real-time measurement of hand/rim force applied by subjects during normal wheelchair operation. An ExpertVision(TM) six-camera video motion capture system collected trajectory data of markers attached on anatomical positions. The CGMM was used to simulate and animate muscle action by using an optimization technique combining observed muscular motions with physiological constraints to estimate muscle contraction forces during wheelchair propulsion. The CGMM provides results that satisfactorily match the predictions of previous work, disregarding minor differences which presumably result from differing experimental conditions, measurement technologies and subjects. Specifically, the CGMM shows that the supraspinatus, infraspinatus, anterior deltoid, pectoralis major and biceps long head are the prime movers during the propulsion phase. The middle and posterior deltold and supraspinatus muscles are responsible for arm return during the recovery phase. CGMM modelling shows that the rotator cuff and pectoralis major play an important role during wheelchair propulsion, confirming the known risk of injury for these muscles during wheelchair propulsion. The CGMM successfully transforms six-camera video motion capture data into a technically useful and visually interesting animated video model of the shoulder musculoskeletal system. The CGMM further yields accurate estimates of muscular forces during motion, indicating that this prototype modelling and analysis technique will aid in study, analysis and therapy of the mechanics and underlying pathomechanics involved in various musculoskeletal overuse syndromes.
Relation:	UROLOGIA INTERNATIONALIS 73(1):41-46
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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